Type 2 Diabetes mellitus is a disease characterized by chronically elevated blood glucose levels, even when fasting largely due to increased endogenous glucose production. In liver, glucose-6-phosphatase catalyses the terminal step of glycogenolysis and gluconeogenesis. The classical role of glucose-6-phosphatase in the liver is the production of glucose for release into the blood. This correlation between type 2 diabetes and glucose-6-phosphatase makes this enzyme an appealing drug target for control of blood glucose levels as its inhibition would directly prevent the release of free glucose into the blood stream. Aims of the study were to assess the effects of anti-diabetic drugs( metformin and metformin plus glibenclamide) on Glucose-6-phosphatase activity, serum leptin concentration, Fasting plasma glucose (FPG) , Glycated hemoglobin (HbA1c%) and lipid profile in type 2 diabetic patients and to study the factors that affect the binding between Glucose-6-Phosphatase and biotin antibody in all diabetic patients and control. Subjects, Materials and Methods: This study includes (84) subjects, their age ranged from (40 to 54) years. (20) subjects were heal
This book which is providing for the treatment of diabetic neuropathy.Diabetes mellitus is defined as an endocrine disorder resulting from either a deficiency in production and release of insulin into blood stream (Type I) or resistance to insulin in body (Type II). Recently published findings revealing that in 2011, the country with the largest numbers of people with diabetes is India.The countries such as India are going to be as many as 80% of all diabetes from the entire world population, there which makes India the diabetic capital of the world. It has been projected that 300 million individuals would be affected with diabetes by year 2025. (WHO). Diabetes has many serious complications including diabetic neuropathy, which presents clinically in many different ways. There is a significant difference between Balance with Strength training and general mobility exercise with walking in reducing the fall risk in subjects with Diabetic Peripheral Neuropathy. This concludes that the Balance and Strength training will reduce the fall risk in subjects with Diabetic Peripheral Neuropathy.
The book has discussed Stochastic Models to understand the processes of metabolism of glucose and insulin more specific to diabetic patients. This study mainly focuses on assessment of glucose/insulin levels through stochastic modeling approach for Type2-diabetes mellitus patients. It also consists of the mechanism of measuring the dynamics of glucose and insulin levels along with the factors like intake of diet, usage of external insulin and physical activity. Measuring the levels of both glucose/insulin through Markov point process is the core area of study. Further, the study has focused on the solving simultaneous differential equations and achieving the approximate values through numerical methods as the model has limitations in getting classical and abstract solutions. The study has many other focusing issues like consumption patterns of average number of glucose molecules and insulin granules in the blood stream. This study has a good scope of usage in health care industry by developing the suitable interface by converting all these mathematical models as user friendly devices by developing relevant computer software and data visualizations methodologies.
In todays era Diabetes Mellitus with its complications has become the most important contemporary & challenging health problem globally. The problem has now reached to pandemic proportion. The prevalence of Diabetes Mellitus is rising all over world due population growth , urbanization , increasing obesity & physical inactivity. Diabetes results when the body makes too little insulin or does not use insulin properly, allowing sugar level to build up in the blood stream . Diabetes Mellitus ,during its course , badly affect all organ & system in our body. The are many herbal medicinal plants have proven antidiabetic & related beneficial effects. Aegle Marmelos leaves is a medicinal antidiabetic property which explained ancient Indian Ayurved classical text. So In this books a clinical research on Aegle Marmelos leaves Anti Diabetic propety explain in details.
Diabetes mellitus is a complex of metabolic disease characterized by hyperglycemia , diminished insulin production, impaired insulin action , or a combination of both resulting in the inability of glucose to be transported from the blood stream into the tissues, which in turn results in high blood glucose levels and excretion of glucose in the urine, The cell functions involved in the action of insulin receptor binding enzyme and transporter activities are controlled by membrane properties . Fatty acids composition of membrane phospholipids are affected by the composition of the dietary fat .Changes in the fatty acids composition of erythrocyte membrane , which are easily accessible cells, reflects changes in that of membrane phospholipids of less accessible tissues . The fatty acids composition of cell membrane can influence membrane associated phenomena such as the interaction between insulin and its receptors. Thus it is from interest to study the relationship between cell membrane phospholipids fractions and their role in insulin action, also to study the role of omega-3 fatty acids in reducing oxidative stress in diabetic rats.